Central cholinergic stimulation causes adrenal epinephrine release.
نویسندگان
چکیده
منابع مشابه
Cholinergic stimulation of vasopressin release in spontaneously hypertensive rats.
Plasma vasopressin (VP) concentration is elevated in spontaneously hypertensive rats (SHRs) relative to their normotensive Wistar-Kyoto (WKY) controls. The possibility that this reflects altered responsiveness of the hypothalamo-neurohypophyseal system (HNS) in SHRs was examined by comparing VP release in response to acetylcholine from organ cultured HNS explants obtained from SHR and WKY donor...
متن کاملCentral cholinergic stimulation affects ocular functions through sympathetic pathways.
Intracerebroventricular (ICV) injection of carbachol into the third ventricle of conscious rabbits increased pupil size and intraocular pressure (IOP). A significant increase of pupil size by 0.6-1.3 mm for 60-90 min was observed with the dose of 1 microgram and an increase of IOP by 1.1-1.9 mmHg for 15-60 min was observed with doses over 10 ng. These responses were due to central cholinergic s...
متن کاملAdrenal epinephrine and norepinephrine release to hypoglycemia measured by microdialysis in conscious rats.
Experiments were conducted in conscious male rats to determine whether hypoglycemia induced by insulin administration preferentially stimulated epinephrine (Epi) or norepinephrine (NE) adrenal medullary chromaffin cells. The release of Epi and NE from the adrenal medulla was continuously monitored using a microdialysis probe of novel design that had been inserted in the adrenal medulla ∼16 h be...
متن کاملSympatho-adrenal stimulation by carbon dioxide and the inhibitory effect of carbonic acid on epinephrine response.
Carbon dioxide serves as a potent stimulus to increase the titer of circulating sympatho-adrenal catechol amines in the cat. Using the denervated nictitating membrane as an assay method the CO2 threshold for adrenal stimulus was determined to be about 1.57~ concentration in alveolar air. Adrenalectomy decreased by 600/, the catechol amine titer initiated by 307~ COS, but hepatectomy was ineffec...
متن کاملCardiac epinephrine synthesis and ischemia-induced myocardial epinephrine release.
OBJECTIVE Phenylethanolamine-N-methyltransferase (PNMT), the enzyme that synthesizes epinephrine (EPI) from norepinephrine (NE) in the adrenal gland, is present in extra-adrenal tissues including heart. Ischemia evokes an excessive NE accumulation in the myocardial interstitial spaces. Therefore, cardiac PNMT activity with high NE levels may contribute to cardiac EPI synthesis and release evoke...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1984
ISSN: 0021-9738
DOI: 10.1172/jci111517